MR and histological findings one week after implantation of neural stem cells.
A. T2-weighted image (TR/TE = 3,000/100 msec) shows hypointense, SPIO-labeled, neural stem cells (curved arrow) in left striatum and hyperintense lesion (arrows) in right striatum, representing intracerebral hemorrhage.
B. T2*-weighted image (TR/TE = 231/10 msec) reveals hypointense, SPIO-labeled neural stem cells (curved arrow) in left cerebral hemisphere.
C. Hematoxylin and eosin staining (objective magnification: × 4) shows intracerebral hemorrhage (arrows) in right striatum with mass effect to corpus callosum and right lateral ventricle (LV).
D. Prussian blue staining (objective magnification: × 4) shows no migration of SPIO-labeled neural stem cells.
E. Immunohistochemical staining (objective magnification: × 4) shows no migration of neural stem cells.