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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: J Neurovirol. 2008 Nov 12;14(5):376–388. doi: 10.1080/13550280802199898

Figure 1.

Figure 1

Schematic of changes in p38 and JNK activation seen in the brain longitudinally throughout SIV infection, as determined by quantitative immunohistochemistry in subcortical white matter. Solid lines depict mean immunohistochemical data obtained from multiple SIV-infected macaques at each time point and presented as percent activation relative to mean uninfected levels (data adapted from Barber et al, 2004). Dashed lines indicate decreased levels of active phoshpo-p38 (Zink et al, 2005) and phospho-JNK observed terminally at 84 days post-infection (p.i.) in minocycline-treated SIV-infected animals (+MC; treatment initiated at 21 days p.i.).