Table 4.
Mayo risk stratification for myeloma: definition of high-risk disease7
| High-risk characteristic | Percentage of newly diagnosed patients with the abnormality (%)1,22,23 |
|---|---|
| Conventional cytogenetics | |
| Deletion of chromosome 13 (monosomy) | 14 |
| Hypodiploidy | 9 |
| Either hypodiploidy or deletion 13 | 17 |
| Fluorescent in situ hybridization (FISH) | |
| t(4;14) | 15 |
| t(14:16) | 5 |
| 17p– | 10 |
| Plasma cell labeling index (PCLI) studies: PCLI ≥3% | 6 |
| Any one of the above high-risk abnormalities | 25–30 |
Reproduced with permission from Rajkumar and Kyle.24 ©Mayo Clinic Proceedings.