Table 1.
Historical contributions to the DNT guideline.
| Date | Event | Summary | References |
|---|---|---|---|
| 1960s–1980s | Published research on DNT and behavioral testing | Evidence that developmental exposure to chemicals and drugs can alter behavioral function in young and adult animals | Irwin 1968, Spyker and Smithberg 1972, Barlow and Sullivan 1975, Butcher et al. 1979, Butcher and Vorhees 1979, Vorhees et al. 1979, Butcher and Nelson 1985, Adams 1986 |
| 1978–1984 | CBTS | Study to examine intra- and interlaboratory reliability and sensitivity of behavioral test methods | Buelke-Sam et al. 1985, Kimmel and Buelke-Sam 1985, Kimmel et al. 1985 |
| 1984 | Cincinnati Test Protocol | Within-laboratory comparison of CBTS test protocol with the Cincinnati Test Protocol | Vorhees 1985a, Vorhees 1985b, Vorhees 1985c |
| 1982–1985 | Collaborative studies of the Japanese Teratology Society | Interlaboratory methods evaluations and assessment of six reference chemicals | Tanimura 1986, Tanimura 1992 |
| 1985–1988 | European Interlaboratory Collaborative Study | Interlaboratory study to assess sensitivity of behavioral test procedures to detect neurotoxicity of methylmercury | Elsner 1986, Elsner et al. 1986, Suter and Schon 1986 |
| 1989 | Williamsburg Workshop | Workshop to evaluate the qualitative and quantitative comparability of animal and human data for DNT | Francis et al. 1990, Kimmel et al. 1990 |
| 1993–1997 | Collaborative studies of the Japanese Teratology Society | Three interlaboratory studies using behavioral teratogens comparability a core battery of tests | Tachibana et al. 1996, Tachibana et al. 1998, Fukunishi et al. 1998, Nishmura et al. 2001 |
| 1995 | IPCS | Interlaboratory study using neurotoxic chemicals to evaluate test validity, reliability, and measurement variability | Catalano et al. 1997, MacPhail et al. 1997, Tilson et al. 1997 |
| 2000 | ILSI workshop on DNT testing | Workshop to review U.S. EPA DNT behavioral test methods, pharmacokinetics, and neuropathology | Cory-Slechta et al. 2001, Dorman et al. 2001, Garman et al. 2001, Mileson and Ferenc 2001 |
| 2003 | Japanese Interlaboratory Study | Interlaboratory study using neurotoxic chemicals to determine sensitivity of behavioral measures | Okazaki et al. 2003 |
| 2003 | Behavioral Test Methods Workshop | Expert workshop to address design, conduct, and analysis of behavioral tests for neurotoxicity evaluation | Slikker et al. 2005 |
| 2004–2008 | ILSI RSI Working Group | Working group focused on variability, statistical analyses, positive controls, identification and analyses, interpretation of treatment-related effects, and application of DNT testing to public health protection | Fenner-Crisp et al. 2005, Crofton et al. 2008, Holson et al. 2008,Raffaele et al. 2008,Tyl et al. 2008 |