Table I.
Summary of the Improved Physicochemical Properties of the Liposomal Alendronate Formulation Prepared in this Study
| Formulation | |||
|---|---|---|---|
| Pre sent study | Previous study | ||
| Size and morphology | nm ± SD | 160 ± 24 | 254 ± 322,a/161 ± 603,a |
| Polydispersity index | <0.1 | >0.3 | |
| Multilamellarityb (%) | 10 | 40 | |
| Stability | Projected Shelf-life | >2.5 year | 1 month |
| Drug leakage (%) | <5 | >20 | |
| Yield | Drug encapsulation (%) | 30 ± 5 | 10 ± 2 |
aCharacterized by >15% of the vesicles at 400 nm, and 1 to 5% in the micron size range
bEstimated % of multilamellar vesicles from the cryo-TEM images