Table II.
Effect of Particle Size on Absorption for Digoxin, Griseofulvin, and Panadiplon as Predicted by the Integrated Absorption Model Proposed by Yu (23)
| Digoxin | ||||
| Simulated dose (mg) | 0.5 | 0.5 | 0.5 | |
| Particle size (μm) | 7 | 13 | 98 | |
| Predicted Fa (%) | 100 | 90 | 20 | |
| Observed Fb (%) | 97 | 78 | 34 | |
| Griseofulvin | ||||
| Simulated dose (mg) | 500 | 250 | 250 | |
| Particle size (μm) | 5 | 30 | 4 | |
| Predicted Fa (%) | 38 | 35 | 58 | |
| Observed Fb (%) | 45 | –a | ||
| Panadiplon | ||||
| Simulated dose (mg) | 10 | 10 | 10 | 10 |
| Particle size (μm) | 8.8 | 25 | 39 | 100 |
| Predicted Fa (%) | 89 | 79 | 73 | 45 |
| Observed Fb (%) | 81 | 74 | 71 | 24 |
aA twofold increase in griseofulvin absorption through micronization was reported