Table 1.
Summary data*
| Patient demographics, treatment, and outcomes | All patients | Planned | Unplanned | p Value |
|---|---|---|---|---|
| Number of patients | 203 | 139 (68%) | 64 (32%) | |
| Age (years) | 56 (range, 10–90) | 57 (range, 10–90) | 53 (range, 22–87) | 0.16 |
| Gender | 0.38 | |||
| Male | 113 (56%) | 74 (53%) | 39 (61%) | |
| Female | 90 (44%) | 65 (47%) | 25 (39%) | |
| American Joint Committee on Cancer stage | ||||
| II | 77 (38%) | 45 (32%) | 32 (50%) | |
| III | 102 (50%) | 75 (54%) | 27 (42%) | |
| IV | 24 (12%) | 19 (14%) | 5 (8%) | 0.33 |
| Size† (cm) | 10.7 (SD, 7.2) | 11.6 (SD, 7.7) | 8.9 (SD, 5.4) | 0.02 |
| Duration of symptoms (months) | 5 (range, 0.5–132) | 5 (range, 0.5–132) | 6 (range, 1–120) | 0.42 |
| Depth† | < 0.0001 | |||
| Subcutaneous | 78 (38%) | 35 (25%) | 43 (67%) | |
| Deep | 125 (62%) | 104 (75%) | 21 (33%) | |
| Resection margins | ||||
| Positive | 6 (3%) | 2 (1%) | 4 (6%) | 0.08 |
| Negative (< 1 cm) | 106 (52%) | 86 (62%) | 20(31%) | 0.08 |
| Negative (≥ 1 cm) | 91 (45%) | 51 (37%) | 40 (63%) | < 0.0001 |
| Radiotherapy | 122 (60%) | 81 (58%) | 41 (64%) | 0.53 |
| Chemotherapy† | 107 (53%) | 83 (60%) | 24 (38%) | 0.003 |
| Disease at reexcision | NA | NA | NA | |
| Positive | 40 (63%) | |||
| Negative | 18 (28%) | |||
| Gross | 6 (9%) | |||
| Amputation | 37 (18%) | 29 (21%) | 8 (13%) | 0.22 |
| Flap and/or STSG† for limb salvage procedures | 22 (13%) | 5 (5%) | 17 (30%) | < 0.0001 |
| Local Recurrence† | 31 (15%) | 9 (6%) | 22 (34%) | < 0.0001 |
| Time to local recurrence (months) | 22 (range, 3–175) | 31 (range, 11–175) | 17 (range, 3–117) | 0.12 |
| Postoperative followup† (months) | 58 (range, 24–212) | 63 (range, 24–212) | 48 (range, 24–132) | 0.04 |
| Disease-specific survival | ||||
| Alive, NED | 107 (53%) | 66 (47%) | 41 (64%) | 0.07 |
| AWD | 11 (5%) | 6 (4%) | 5 (8%) | |
| DOD | 71 (35%) | 54 (39%) | 17 (27%) | |
| DOC | 14 (7%) | 13 (9%) | 1 (2%) | |
* Data provided as mean (SD), median (range), or number (percentage), as appropriate; †significant difference between cohorts; STSG = split-thickness skin graft; NED = no evidence of disease; AWD = alive with disease; DOD = died of disease; DOC = died of other causes; SD = standard deviation; NA = not applicable.