Table II.
Solubility Study of LS (Mean ± Standard Deviation) from Physical Mixture and Solid Dispersions in Comparison with Pure LS
| Product | Solubility (μg/ml) |
|---|---|
| LS | 1.28 ± 0.061 |
| PM | 3.078 ± 0.112 |
| KW | 3.202 ± 0.160 |
| KE | 3.399 ± 0.179 |
| SW | 3.452 ± 0.204 |
| SP | 3.613 ± 0.200 |
| SE | 3.717 ± 0.161 |
n = 3
LS lovastatin, PM physical mixture of lovastatin & modified locust bean gum, KW SDs by kneading method using water, KE SDs by kneading method using ethanol, SW SDs by solvent wetting method SP SDs by spray drying method, SE SDs by solvent evaporation method