Figure 2.

mGluR1 but not mGluR5 antagonism acutely facilitates acquisition of spinal learning. The mGluR1 antagonist CPCCOEt (in 100% DMSO) increased the rate of spinal learning when subjects were tested immediately after drug exposure (A). This effect was most pronounced in the first 5 min of testing, a time point that is associated with molecular plasticity in spinal learning (Gómez-Pinilla et al., 2007). The mGluR5 antagonist MPEP (in 0.9% saline) did not improve spinal learning (B). The shaded region represents SEM over time (n = 8 subjects/group).