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A group I mGluR agonist induces lasting metaplastic inhibition of spinal learning. Subjects that were given DHPG (in 0.9% saline) had impaired spinal learning at test at 24 h, as evident by impaired performance over time (A) and group means (B). The shaded region represents SEM over time; error bars represent SEM for group means (n = 16 subjects/dose). *p < 0.05 from vehicle.
