Figure 5.

PKC activation is necessary for metaplastic inhibition of spinal learning. Uncontrollable shock produced a metaplastic inhibition of spinal learning at testing at 24 h (A, E). Spinal learning was restored by two mechanistically distinct PKC inhibitors BIM (A–D) and chelerythrine (E–G) delivered in 100 and 10% DMSO, respectively. Group means are depicted in D and G. The shaded region represents SEM over time; error bars represent SEM for group means (n = 8 subjects/group). *p < 0.05 from all groups except for shocked subjects in middle dose; **p < 0.05 from all other groups.