Table 1.

Top 5 networks generated from IPA for transcripts that increase 2-fold in homozygous mutant animals compared to wild type.
Network ID	Genes in Network	score	# Focus genes	Top Categories
1	AKT2, BRD8, CACNA1A, CDH1, CDK5, CHRNA2, CHRNA6, CHRNA7, CHRNA9 CHRNA10, CHRNB3, CHRND, DAB1, FHL1, GCN5L2, HGF, HRB2, INSM1, ITGB5, MAPK1 MPZ, NEF3, NEFH, NOTCH1, NOV, PHOX2A, PPP1R1A, PRKCA, PSMD3, RET, SLC1A1 SOX10, STX1A, TACC3, TH	23	18	Cardiovascular Disease, Cell-To-Cell Signaling and Interaction, Nervous System Development
2	AXL, BAD, BRRN1, C14ORF126, CALCR, CDC2, CDK5RAP3, EBI3, FLT3, GAS6, GPX3 GRB2, IFNGR1, IGHE, IL13, IL13RA1, IL13RA2, IL27RA, IL4R, MARCKS, NDUFA13 PHKA2, PIM2, PRKCQ, PTPRE, QSCN6, REG3A, REPS2, SERPINB3, SERPINB4 SLC6A4, SNCA, SOCS5, STAT3, UCHL1	21	17	Cell Death, Cellular Growth and Proliferation Hematological Disease
3	ADFP, ANGPTL4, APBA1, APOA5, ARF6, ARFGAP1, CBX2, CCS, CPXM2, EGR1, FDPS FTL, GGA1, GGA2, GGA3, GH1, HBB, IDH1, ITPR2, LGALS9, LIN7B, LNPEP, LPL LRRC8C, M6PR, PMM1, PPARG, RPL29, SIM1, SLC2A4, SST, SSTR1, SSTR4 SSTR5, XRCC1	19	16	Cell Morphology, Cell Cycle, Reproductive System Development and Function
4	ABCC3, ARFGAP3, CASP12, CKMT2, CREB3, FABP1, FCGR1A, FCGR2B, FCGR3A FGR, FOXO1A, KIF20A, KLHDC2, KLRC1, KLRD1, KLRK1, LAMA3, LAMA5, LAMB3 LAMC2, LIPE, MAP3K5, MAPK13, MLANA, MTTP, P4HB, RPS6KA5, SLK, STAC, STMN1 TEK, TIE1, TNF, TNNC1, TXN	18	15	Inflammatory Disease, Skeletal and Muscular Disorders, Lipid Metabolism
5	CBX7, CCNG1, CDKN2A, CRABP1, EZH2, FEN1, FOS, HAPLN1, IDE, IGF1, IGF2, IGH-3 IGHM, IL6, IL19, IL4R, KIF11, KIFC1, LIG1, MMP10, PCSK4, PRIM1, PSME1, PSME2, RAG1	18	15	Cancer, Cell Cycle, Reproductive System Disease
Significant networks generated from IPA for transcripts that decrease 2-fold in homozygous mutant animals compared to wild type.
Network ID	Genes in Network	score	# Focus genes	Top Categories
1	BST1, CCR2, CD40LG, CDX2, CMA1, COL17A1, CYR61, F10, GBP1, GDI2, GLA HBB-B2, HLA-DRB1, IFNG, IL15, IL10RA, IL18R1, IL2RA, KLRK1, MAF, MMP9, NFE2L1 NOV, NR1H2, OAS1, OGN, PLP1, PRG1, PSAP, RSAD2, SERPINA5, SORL1, TFPI2 TIMP1, TYRP1	52	35	Immunological Disease, Cellular Movement Inflammatory Disease
2	ABCF2, ACP5, BGLAP, CPA3, CTSB, DACH1, EDD1, EDG1, EYA3, FOS, GAST HOXD10, HSD3B1, IBSP, INS, IRS2, IRS3, KIFAP3, KRT18, LYZ, NACA, NEK1, NRIP1 PC, PDPK1, PGAM2, PPARG, PSCD3, REN, RUNX1, SMAD3, SNW1, TSC1, VAV2 YWHAQ	52	35	Gene Expression, Carbohydrate Metabolism Cellular Development
3	ALDOB, ANXA1, BIRC1, BIRC4, CAPN2, CASP9, CDKN1B, CEP170, COX5A, COX6B2 COX7A1, CSND, CYP1B1, CYP3A2, DKK1, E2F3, ESR1, EXPI, FGB, GCG, GDF11 HNF4A, KIF5C, MAP3K7, MARK1, MCL1, PHLDB2, PLK1, PTEN, PTGDR, PTGS2, THBD WNK1, WNT11, YWHAG	49	34	Cancer, Cell Death, Reproductive System Disease
4	ADRA2A, APS, ATAD3A, CAPN2, CAPZB, CDC2L1, CTSB, CUL1, DDIT3, DDX5, DDX17 DDX50, DHX36, DUB2, FBL, FBXO15, HAS2, HNRPH1, HNRPU, HRAS, IGLL1, LGTN MGST3, MRPL12, MYBL1, MYC, PPID, RHOB, RPL32, SCEL, SLC25A5, SLC2A2 TNFRSF10B, VDAC2, XIST	16	17	Cell Death, Hepatic System Disease, Cancer
5	ARHGAP29, BRD4, CALM1, CD97, CISH, CSF3, CSF2RA, CSF2RB, CSF2RB2, CSF3R CTLA4, EMR1, ES1, FOXD3, GADD45B, GADD45G, HDC, HOXC9, IL3, IL3RA, INPP5D KDR, LTA, MAPKAPK2, MID1, NCF1, PDE1A, PIM1, POU3F2, RPS14, SELL, STT3A TFDP1, TNFRSF1B, ZNF38	13	15	Hematological System Development and Function Immune and Lymphatic System Development and Function, Tissue Morphology