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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Neuropharmacology. 2008 Jul 12;56(1):198–207. doi: 10.1016/j.neuropharm.2008.07.004

Figure 6.

Figure 6

The effect of nitrendipine on zolpidem pharmacology and GABA reversal potential. (A) Enhancement of 3 μM GABA currents by zolpidem (ZOL) significantly increased at 48 h recovery after 4 h hypoxia (ρ<0.01, one way ANOVA). NT (3 μM) during hypoxia not only prevented the increase in enhancement of GABA currents by ZOL, but significantly reduced ZOL enhancement at 48h recovery (p<0.05, student t test). (B) GABA I–V relationship in control conditions (filled squares), and at 24 h (open triangles) and 48 h (open diamonds) recovery after 4 h hypoxia in the presence of NT. (C) Summary of changes in ECl in control conditions or hypoxia conditions with or without NT. In the presence of NT during hypoxia, there was no difference in ECl between control and hypoxia-treated neurons. Data represents mean ± SEM; the n for each condition is shown at the appropriate symbol.