Table 2. Maximal GABAAR Currents after Hypoxia and Recovery.
Maximal GABA-evoked peak currents at specified recovery times after 3 different hypoxic durations. NT= nitrendipine (3 μM).
| Hypoxia | Control (pA) | 0 h Recovery (pA) | 24 h Recovery (pA) | 48 h Recovery (pA) |
|---|---|---|---|---|
| Duration | Mean ± SEM (n) | Mean ± SEM (n) | Mean ± SEM (n) | Mean ± SEM (n) |
| 2 h | 4848 ± 376 (9) | 3924 ± 281 (8) | 3791 ± 208 (9)* | 5303 ± 497 (9) |
| 4 h | 4289 ± 459 (10) | 2813 ± 246 (9)* | 3445 ± 547 (7) | 2362 ± 239 (10)** |
| 8 h | 4290 ± 505 (10) | 2872 ± 502 (6) | 3551 ± 310 (8) | 3334 ± 338 (9) |
| 4 h + NT | 6341± 484 (11)* | 6748 ± 820 (8)*** | 5409 ± 945 (8) | 6212± 524 (9)*** |
*
p<0.05,
**
p<0.01,
***
p<0.001 compared to control, t test with Bonferroni correction after one-way ANOVA. For 4 h + NT, comparisons are made to 4 h control and post-hypoxic time points; post-hypoxic values did not differ from control in the 4h + NT group.