Table 1.
Cardiopulmonary variables
| Table 1.1 | ||||||
|---|---|---|---|---|---|---|
| Parameter | Group | BL | 3 h | 6 h | 12 h | 18 h |
| Temp (°C) | Sham | 39.4 ± 0.1 | 39.4 ± 0.1 | 39.4 ± 0.1 | 39.3 ± 0.1 | 39.2 ± 0.1 |
| IL-2 | 39.5 ± 0.1 | 40.5 ± 0.2#† | 40.0 ± 0.3† | 39.6 ± 0.1 | 40.4 ± 0.2#† | |
| IL-2 + WW-85 | 39.3 ± 0.1 | 39.6 ± 0.1* | 39.5 ± 0.2* | 39.7 ± 0.2 | 39.9 ± 0.1#* | |
| HR (bpm) | Sham | 97 ± 5 | 92 ± 5 | 98 ± 7 | 101 ± 7 | 96 ± 5 |
| IL-2 | 103 ± 5 | 129 ± 8#† | 137 ± 7#† | 125 ± 6#† | 114 ± 4 | |
| IL-2 + WW-85 | 97 ± 3 | 102 ± 2* | 110 ± 3* | 108 ± 3* | 103 ± 3 | |
| CO (L/min) | Sham | 5.28 ± 0.28 | 5.35 ± 0.31 | 5.13 ± 0.20 | 5.15 ± 0.28 | 5.04 ± 0.37 |
| IL-2 | 6.01 ± 0.24 | 5.63 ± 0.29 | 5.36 ± 0.44 | 6.59 ± 0.49† | 5.64 ± 0.30 | |
| IL-2 + WW-85 | 5.55 ± 0.10 | 4.96 ± 0.16 | 5.39 ± 0.22 | 5.27 ± 0.14* | 5.15 ± 0.17 | |
| MPAP (mm Hg) | Sham | 21 ± 1 | 23 ± 1 | 23 ± 1 | 24 ± 1 | 22 ± 1 |
| IL-2 | 20 ± 1 | 28 ± 1#† | 25 ± 2# | 24 ± 0# | 25 ± 1# | |
| IL-2 + WW-85 | 20 ± 1 | 22 ± 1* | 23 ± 2 | 22 ± 1 | 22 ± 1 | |
| Qs/Qt (Ratio) | Sham | 0.17 ± 0.03 | 0.17 ± 0.02 | 0.15 ± 0.02 | 0.15 ± 0.03 | 0.18 ± 0.03 |
| IL-2 | 0.13 ± 0.02 | 0.20 ± 0.03 | 0.23 ± 0.06# | 0.21 ± 0.02# | 0.19 ± 0.02 | |
| IL-2 + WW-85 | 0.16 ± 0.03 | 0.15 ± 0.02 | 0.17 ± 0.02 | 0.18 ± 0.02 | 0.16 ± 0.01 | |
| Table 1.2 | ||||||
|---|---|---|---|---|---|---|
| Parameter | Group | 24 h | 30 h | 36 h | 42 h | 48 h |
| Temp (°C) | Sham | 39.3 ± 0.1 | 39.2 ± 0.1 | 39.3 ± 0.1 | 39.4 ± 0.1 | 39.3 ± 0.1 |
| IL-2 | 39.6 ± 0.1 | 39.4 ± 0.1 | 39.8 ±0.2† | 40.3 ± 0.1#† | 39.5 ± 0.1 | |
| IL-2 + WW-85 | 39.3 ± 0.1 | 39.3 ± 0.1 | 39.6 ± 0.1 | 39.9 ± 0.3#† | 39.4 ±0.1 | |
| HR (bpm) | Sham | 102 ± 6 | 104 ± 6 | 106 ± 5 | 104 ± 7 | 106 ± 7 |
| IL-2 | 126 ± 9#† | 114 ± 5 | 116 ± 5 | 105 ± 6 | 111 ± 3 | |
| IL-2 + WW-85 | 100 ± 2* | 100 ± 4 | 99 ± 3 | 101 ± 3 | 94 ± 3 | |
| CO (L/min) | Sham | 5.39 ± 0.45 | 5.56 ± 0.46 | 5.09 ± 0.37 | 5.71 ± 0.45 | 5.35 ± 0.32 |
| IL-2 | 6.18 ± 0.44 | 6.45 ± 0.37 | 6.04 ± 0.29 | 5.27 ± 0.21 | 5.55 ± 0.28 | |
| IL-2 + WW-85 | 5.13 ± 0.15 | 5.15 ± 0.23* | 5.27 ± 0.33 | 4.91 ± 0.17 | 4.84 ± 0.24 | |
| MPAP (mm Hg) | Sham | 23 ± 1 | 23 ± 1 | 23 ± 1 | 22 ± 1 | 23 ± 1 |
| IL-2 | 23 ± 2 | 23 ± 1 | 22 ± 1 | 22 ± 1 | 20 ± 1 | |
| IL-2 + WW-85 | 21 ± 1 | 22 ± 2 | 22 ± 2 | 22 ± 1 | 20 ± 1 | |
| Qs/Qt (Ratio) | Sham | 0.17 ± 0.02 | 0.13 ± 0.02 | 0.18 ± 0.04 | 0.16 ± 0.03 | 0.15 ± 0.02 |
| IL-2 | 0.18 ± 0.02 | 0.16 ± 0.01 | 0.17 ± 0.02 | 0.20 ± 0.02 | 0.18 ± 0.04 | |
| IL-2 + WW-85 | 0.14 ± 0.01 | 0.15 ± 0.02 | 0.17 ± 0.02 | 0.14 ± 0.01 | 0.15 ± 0.01 | |
Legend: Temp, Temperature; HR, Heart Rate; CO, Cardiac Output; MPAP, Mean Pulmonary Artery Pressure; Qs/Qt, Pulmonary Shunt Fraction; Mean ± SEM; Significance was assumed when p was less than 0.05;
#
vs. baseline,
*
vs. IL-2,
†
vs. Sham