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. 2008 Dec 22;5:157. doi: 10.1186/1743-422X-5-157

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Copyright © 2008 Ammayappan et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Classical Genome Organization of IBV-Ark DPI. The genome of Ark DPI is 27,620 nt long, excluding poly (A) tract. Middle: ten genes and its ORFs. Ribosomal frameshift and position of transcriptional regulatory sequences (TRS) of each gene is indicated. Top: putative domains of ORF1a/1b polyprotein: nsp-non-structural protein, Ac-acidic domain, X-unknown domain X, PL1- papain like proteinase1, PL2-papain like proteinase 2; Y-unknown domain Y; HD-hydrophobic domain, 3CL-3C-like proteinase, G-Growth factor like protein, RdRp-RNA dependent RNA polymerase, Hel-helicase, ExoN-exoribonuclease, Ne-nidoviral uridylate-specific endoribonuclease, MT- 2'-O-ribose methyltransferase. Bottom: details of spike protein; SP-signal peptide, RRSRR/S- spike protein cleavage site between 544 and 545aa, TM-transmembrane domain of spike protein.