Table 1.
Variable | Mcl-1 levels |
P | |
---|---|---|---|
< 0.85, no. (%) | ≥ 0.85, no. (%) | ||
Rai stage | .66 | ||
Low | 1 (4) | 2 (9) | |
Intermediate | 12 (43) | 10 (46) | |
High | 15 (54) | 10 (46) | |
Sex | .30 | ||
Male | 24 (86) | 16 (73) | |
Female | 4 (14) | 6 (27) | |
Age, y | .22 | ||
< 70 | 18 (64) | 18 (82) | |
≥ 70 | 10 (36) | 4 (18) | |
ECOG PS | .42 | ||
0 | 18 (64) | 10 (46) | |
1 | 9 (32) | 9 (41) | |
2 | 1 (4) | 2 (9) | |
3 | 0 (0) | 1 (5) | |
CD38 (> 30) | 10 (36) | 6 (27) | .56 |
ZAP-70+ cells (> 20) | 7 (32) | 7 (33) | .92 |
IgVH status unmutated (> 98) | 19 (68) | 16 (76) | .75 |
FISH | .82* | ||
Normal | 2 (7) | 2 (9) | |
+12 | 8 (29) | 3 (14) | |
11q− | 6 (21) | 6 (27) | |
17p− | 1 (4) | 1 (5) | |
6q− | 0 (0) | 1 (5) | |
13q− | 10 (36) | 9 (41) | |
Other | 1 (4) | 0 (0) | |
No. of genetic defects | .37* | ||
0 | 2 (7) | 2 (9) | |
1 | 13 (46) | 15 (68) | |
2+ | 13 (46) | 5 (23) | |
Bone marrow pattern | .37 | ||
Diffuse | 9 (39) | 11 (55) | |
Not diffuse | 14 (61) | 9 (45) | |
Outcome measures | |||
MRD negative | 13 (57) | 4 (19) | .01* |
Responders | 23 | 19 | .16 |
CR | 15 (65) | 7 (37) | |
nPR | 5 (22) | 6 (32) | |
PR | 3 (13) | 6 (32) | |
Median PFS | 50.8 mo | 18.7 mo | .02 |
Exact P value.