Figure 5.
Parenchymal hemorrhage in the brain after disruption of the fII gene. (A) Normal hindbrain and cerebellum from a control mouse. (B,C) Brain sections taken from Mx+fIIlox/− mice 4 to 6 days after poly I:C. A frequent site of hemorrhage in the brain parenchyma was the medulla and the hindbrain near the cerebellum. (D) Normal hippocampal formation in a wild-type mouse. (E,F) Hemorrhage was observed in and around the hippocampal region and into the lateral ventricles in mice with conditionally deleted fII. *Areas of hemorrhage. MED indicates medulla; CB, cerebellum; MB, midbrain; CTX, cortex; CA, Ammon horn; DG, dentate gyrus; Th, thalamus; VL, lateral ventricle. Scale bars represent 100 μm.