Figure 4. Prolonged Synaptic Currents in IHCs Are Blocked by Strychnine.

(A) Superimposed representative traces from individual cells of nAChR-only sIPSCs in IHCs from a Chrna9^wt/wt; (27 events) and a Chrna9^{L9′T/L9′T} (27 events) mice at a V _hold (Vh) of −82 mV.

(B) Superimposed representative traces from individual cells of nAChR+SK synaptic currents in IHCs at a V _hold of −90 mV from a Chrna9^wt/wt (84 events) and a Chrna9^L9′T/L9′ (16 events), and of −40 mV from a Chrna9^wt/wt (54 events) and a Chrna9^L9′T/L9′ (14 events). The representative traces shown are the average of the different events in one cell (number of cells per experiment indicated in Table 1). WT, wild type.

(C) Representative traces (n = 4 IHCs, 2 animals) of synaptic currents evoked by 40 mM external K⁺ at V _hold of −90 mV in Chrna9^L9′T/L9′. The blow-ups show IPSCs, which disappear in the presence of 300 nM strychnine.