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. Author manuscript; available in PMC: 2009 Jan 17.
Published in final edited form as: Curr Opin Cell Biol. 2008 May 29;20(3):334–340. doi: 10.1016/j.ceb.2008.04.008

Figure 1.

Figure 1

Transcription factors implicated in P-TEFb recruitment and function. Activators may recruit P-TEFb directly (e.g. Tat, c-Myc), or indirectly through binding to Brd4. P-TEFb recruitment is also linked to H3S10P, which can be mediated by MSK1,2 or Pim1, which can be recruited through c-Myc:TRRAP complexes. TRRAP is a frequent target of DNA activators and associates with HAT complexes that acetylate chromatin and stabilize binding of Brd4. P-TEFb functionally cooperates with proteins like SKIP to activate transcription and RNAPII CTD phosphorylation links elongation with downstream events required for gene expression.