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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Nat Chem Biol. 2009 Jan 4;5(2):100–107. doi: 10.1038/nchembio.137

Figure 1. Chemical structure and potency of IWR and IWP compounds.

Figure 1

(a) Structure and potency of IWR compounds. Two IWR compounds that differ by only a single methyl group and that share similar IC50's (as determined in L-Wnt-STF cells; upper right of graphs) were designated Class | compounds. The remaining three IWRs which share structural similarity (see also Supp. Fig. 3) were designated Class || compounds. (b) Structure and potency of IWP compounds. All IWP compounds share structural similarity and IC50's with IWP compounds 2-4 sharing the same core structure (IWP-2) and differing only by either the presence of an additional fluoro or methoxy adduct (IWP-3 and IWP-4, respectively).