Table II.
The Predictions of Drug Resistance Based on the Predicted FV Values
| Resistance |
||||
|---|---|---|---|---|
| Position | Experimental Ki (mut)/Ki (wt) | FV | Experiment (prediction) | Accuracy |
| Saquinavir | ||||
| V32 | 1.6-7.3 (V32I)50 | -0.1 ± 0.0 | N (N) | 75% |
| M46 | 1.0 (M46I)51 | +2.6 ± 0.4 | N (N) | |
| I47 | 1.0 (I47V)51 | +5.1 ± 0.3 | N (N) | |
| G48 | 13.5 (G48V)52 163.6 (G48V)53 | +8.0 ± 1.3 | Y (N) | |
| I50 | 21.0 (I50V)51 | +0.6 ± 0.1 | Y (N) | |
| V82 | 0.7-3.7 (V82A/F/I)50 3.3-7.3 (V82F/A/I)54 | -0.1 ± 0.3 | N (N) | |
| I84 | 5.8 (I84V)50 10.7 (I84V)54 12.0 (I84V)51 | -0.4 ± 0.0 | N (N) | |
| L90 | 3.0 (L90M)52, 55 20.7 (L90M)53 | -0.0 ± 0.1 | N (N) | |
| Amprenavir | ||||
| M46 | 1.0 (M46I)51 | +2.5 ± 0.3 | N (N) | 100% |
| I47 | 1.0 (I47V)51 | +4.0 ± 0.2 | N (N) | |
| G48 | 3.5 (G48V)53 | +13.4 ± 1.3 | N (N) | |
| I50 | 83.0 (I50V)51 | -1.1 ± 0.6 | Y (Y) | |
| V82 | 0.4-3.3 (V82A/F/I)54 | +0.0 ± 0.1 | N (N) | |
| I84 | 23.0 (I84V)51 2.7 (I84V)54 | -0.7 ± 0.1 | Y (Y) | |
| L90 | 2.7 (L90M)53 | -0.1 ± 0.2 | N (N) | |
| Ritonavir | ||||
| M46 | 4.0 (M46I)51 | +2.5 ± 0.2 | N (N) | 86% |
| I47 | 3.0 (I47V)51 | +4.2 ± 0.5 | N (N) | |
| G48 | 66.7 (G48V)53 | +9.4 ± 1.9 | Y (N) | |
| I50 | 10.0 (I50V)51 | -0.0 ± 0.4 | N (N) | |
| V82 | 0.8-14.7 (V82A/F/I)54 | -0.1 ± 0.3 | N (N) | |
| I84 | 11.2 (I84V)54 20.0 (I84V)51 | -0.7 ± 0.2 | Y (Y) | |
| L90 | 6.7 (L90M)53 | -0.0 ± 0.0 | N (N) | |
| Indinavir | ||||
| V32 | 8.0 (V32I)50 | -0.5 ± 0.2 | N (Y) | 86% |
| M46 | 4.3 (M46I)50 | +2.6 ± 0.6 | N (N) | |
| I47 | 3.0 (I47V)51 | +4.4 ± 2.3 | N (N) | |
| G48 | 6.3 (G48V)53 | +11.3 ± 1.8 | N (N) | |
| V82 | 0.6-6.4 (V82A/F/I)54 6.9-84.7 (V82A/F/I)50 | -0.6 ± 0.2 | Y (Y) | |
| I84 | 2.6 (I84V)54 10.0 (I84V)50 | -0.4 ± 0.3 | N (N) | |
| L90 | 5.8 (L90M)53 | -0.0 ± 0.3 | N (N) | |
| Nelfinavir | ||||
| G48 | 1.0 (G48V)53 | +13.0 ± 0.1 | N (N) | 100% |
| V82 | 0.8-17.5 (V82F/A/I)54 | +0.5 ± 0.5 | N (N) | |
| I84 | 3.5 (I84V)54 | -0.4 ± 0.2 | N (N) | |
| L90 | 3.5 (L90M)53 | -0.0 ± 0.5 | N (N) |