Figure 3. Donor B cells are not required for induction of stable chimerism and tolerance.
(A) B10.S mice received conditioning as in Methods followed by transplantation with BMCs from wt B6 or B cell-deficient μMT mice. Incidence of donor chimerism in the granulocyte lineage is shown (n = 7–8/group; one representative experiment of 2 is shown). (B) Levels of chimerism (mean ± SEM) in granulocytes and CD4 T cells are shown for groups in panel A. (C) The groups in panel A were grafted with donor B6 or 3rd party B10.RIII skin 2 weeks after BMT, and graft survival is shown over 100 days.