(A) Schematic diagram of WNrep and HP4.9, HP17.0 and NS5mut variants. ΔG values are in kcal/mol. (B) Early and late translation events in WNrep-transfected cells. Transfected cells were assayed for Rluc activity at 2, 24, 48, 72 and 96 hours post-transfection. Data are averages of at least 4 experiments and error bars indicate SD. RLU, relative luciferase units. *, p < 0.002 relative to WT by Wilcoxon rank sum test.