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. Author manuscript; available in PMC: 2009 Sep 2.
Published in final edited form as: Biochemistry. 2008 Aug 9;47(35):9090–9097. doi: 10.1021/bi8008455

FIGURE 7.

FIGURE 7

Three-dimensional model of the OATP1B3/CCK-8 complex. A side view (A) and a view from the intracellular side (B) are presented. Helical segments of the protein are shown in cylinders; the three residues Y537, S545 and T550 in TM10 are shown in ball-and-stick and in orange; CCK-8 is shown in ball-and-stick and in purple. CCK-8 is located in the putative translocation pathway which is formed by TMs 1, 2, 4, 5, 7, 8, 10 and 11. The side chains of Y537 and S545 are located on one side of TM10 facing towards the translocation pathway, while T550 is located on the other side of TM10.