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. Author manuscript; available in PMC: 2009 Dec 10.
Published in final edited form as: FEBS Lett. 2008 Nov 4;582(29):4039–4046. doi: 10.1016/j.febslet.2008.10.043

Figure 3.

Figure 3

Inhibition of GJIC coincides with GJ internalization in response to GPCR activation by inflammatory mediators. (A-D) GJIC was assessed by scrape loading dye transfer in untreated PAEC monolayers (A); and following 30-min. incubations with 50nM endothelin-1 (B), 10U/mL thrombin (C), or 240nM mastoparan (D). (E-H) Scans of fluorescence intensity measured along lines indicated in A-D. The area under the curve for untreated cells was set as 100% dye transfer, and the areas of the curves for treated cells were expressed as a percentage of untreated control.