Preservation of spatial memory by chronic administration of ibuprofen inTg2576 mice. (a) Experimental design. (b) Spatial working memory in ibuprofen-treated and control Tg2576 mice, assessed using the T-maze. Data are the mean±SEM of the percentage of correct responses averaged over two days for each mouse (F = 5.6, P = 0.02, for treatment effect by multiple-measures ANOVA, **P<0.01 by t-test). Numbers of mice are in parentheses. (c) Spatial reference memory in ibuprofen-treated and control Tg2576 mice, assessed using the Morris water-maze. Data are the mean±SEM of the MPS for each mouse (F = 5.13, *P = 0.03, for treatment effect by ANOVA).