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. Author manuscript; available in PMC: 2009 Jan 19.
Published in final edited form as: Brain. 2008 Mar;131(Pt 3):651–664. doi: 10.1093/brain/awn008

Fig. 6.

Fig. 6

Aβ levels inTg2576 mice. (a) No significant effects of treatment on Aβ levels in mice treated with NSAIDs from 11.5 to 13 months of age. Forebrain Aβ40 and Aβ42 levels were measured by ELISA in SDS and formic acid (FA) fractions. Numbers of mice denoted inside bars. (b) No significant effects of treatment on Aβ42 levels in 2-month-old mice treated with NSAIDs for 30 days. Brains were extracted in SDS and Aβ42 levels were measured by ELISA. (c) Aβ*56 levels are not modulated by ibuprofen treatment. Tg2576 mice (+) and non-transgenic littermates (−) were treated with ibuprofen (Ib) or control (C) diets from 11.5 to 13 months of age. Forebrain Aβ*56 was measured in membrane-enriched extracts by Western blotting (WB; 100 μg protein/lane) using 6E10 monoclonal antibodies (1:10,000). CTFβ and monomeric Aβ (1-mer) levels also showed no significant alterations.