. Author manuscript; available in PMC: 2009 Jan 19.

Published in final edited form as: Brain. 2008 Mar;131(Pt 3):651–664. doi: 10.1093/brain/awn008

Table 1.

Drug levels in NSAID-treated mice

Drug	3 months old			13 months old
	Brain (μM)	Serum (μM)	Brain/Serum Ratio (%)	Serum (μM)
Ibuprofen	1.73 ± 0.21 (12)	63.00 ± 8.83 (12)	2.87% ± 0.17 (12)	28.81 ± 7.18 (10)
Naproxen	1.72 ± 0.46 (6)	82.51 ± 23.94 (6)	2.35% ± 0.36 (6)	51.65 ± 15.34 (10)
MF tricyclic	1.99 ± 0.4 (6)	4.81 ± 0.74 (6)	40.14% ± 2.39 (6)	3.72 ± 0.62 (10)

Ibuprofen, naproxen and MF tricyclic are present in the brain and serum of g2576 mice following oral NSAID treatment for 30 days (3 months old) and 40 days (13 months old) respectively. Data are presented as mean±SD (no. of mice).