. Author manuscript; available in PMC: 2009 Oct 1.

Published in final edited form as: Int J Pharm. 2008 Jul 5;362(1-2):126–132. doi: 10.1016/j.ijpharm.2008.06.025

Table 2.

Stability of THC-HG (5% w/w) in PEO matrices containing various antioxidants. The matrices (n = 3) were fabricated at 110 ° C and stored at 25 ° C/ 60% RH.

		% THC-HG Degradation

Antioxidant/ Drug	% Antioxidant	1 Month	2 Months	3 Months
Pure THC-HG	-	53.3 ± 2.1	62.2 ±1.3	74.5 ±2.5
PEO N-80	0.0	39.1 ± 2.3	45.6 ±3.6	55.4±1.4
BHT	0.2	2.6 ±0.4	3.7 ±1.2	7.6 ±1.4
BHA	0.2	5.7 ±1.4	6.5 ±0.5	10.7 ±2.4
Propyl gallate	0.5	18.2 ±3.4	25.8 ±5.9	27.2 ±4.1
Ascorbic acid	0.5	7.7 ±5.1	11.6 ±4.3	14.1 ±3.5
Ascorbic acid	1.0	5.3 ±1.1	6.6 ±0.4	8.2 ±1.4
EDTA	0.05	15.3 ± 1.5	21.6 ± 2.1	29.3±4.2