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Decreased expression of SIRT1 by cytokine in RIN cells (A) and isolated rat islets (B). RIN cells (5 × 106) or islets (30) were treated with IL-1β (2 ng/ml) alone or IL-1β and IFN-γ (100 units/ml). After 48 h of incubation, Western blotting for SIRT1 was conducted. C: Protein bands were detected using the enhanced chemiluminescence detection system and analyzed by imaging densitometry. Each value represents the mean ± SE of six independent experiments. **P < 0.01 vs. untreated control.
