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. 2009 Feb;58(2):422–432. doi: 10.2337/db07-1762

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Copyright © 2009, American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — ER Ca²⁺ dynamics during acute SERCA inhibition and IP₃R activation in MIN6 β-cells. A: Subcellular colocalization of mRFP targeted to the ER using the KDEL protein sequence and DIER cameleon in transfected MIN6 cells. B: A total of 1 μmol/l thapsigargin evoked a gradual depletion of luminal ER Ca²⁺. An average trace is shown in black (n = 14 cells), and profiles from individual cells are shown to illustrate the response heterogeneity. C: Repeatable and reversible lowering of ER luminal Ca²⁺ due to IP₃R activation by successive carbachol (Cch) treatments as indicated. An average response is shown in the black trace (n = 9 cells) along with representative single cell traces. (Please see http://dx.doi.org/10.2337/db07-1762 for a high-quality digital representation of this figure.)