FIG. 1.

Experimental design, birth weight, and growth curves. A: Experimental design, including breeding scheme for second-generation (F₂) offspring. Circles designate females and squares designate males. Note that mating pairs were nonsiblings. Metabolic analysis was performed in males only. B: Body weight at birth for F₂ offspring. C: Postnatal growth curves for F₂ male mice. For all panels, values are means ± SE (n ≥ 15 mice/group). *P < 0.05; **P < 0.01 vs. C♀-C♂ (ANOVA).