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. 2009 Feb;58(2):469–477. doi: 10.2337/db08-1328

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Copyright © 2009, American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Jak/Stat canonical pathway in human diabetic nephropathy as assessed by Ingenuity Pathway Analysis software. The Jak/Stat family members represented include Jak-1, -2, and -3 and Stat-1, -2, -3, -4, -5A, -5B, and -6. The mRNA expression changes for Jak/Stat family members in early (PIMA Indians, n = 22–24) (left panel) and progressive (European, n = 7–11) (right panel) human diabetic nephropathy (DN) are indicated in red for increased expression and green for decreased expression, compared with the corresponding control group (LD + MCD, n = 7–12). 2000–2008 Ingenuity Systems. All rights reserved. LD, living donor; MCD, minimal change disease.