TABLE 3.
Association of rs8050136 in FTO with maximum BMI and fat cell size in full-heritage Pima Indians
| Trait | Mean ± SD (top row) and number of subjects (bottom row)
|
P value general analysis (top row) and within-family analysis (bottom row)
|
|||
|---|---|---|---|---|---|
| CC | CA | AA | Additive | Recessive | |
| BMI (kg/m2) | 36.1 ± 8.2 | 36.7 ± 8.0 | 37.7 ± 8.3 | 0.002 | 0.005 |
| 1975 | 624 | 55 | 0.002 | 0.001 | |
| Fat cell size (ng lipid/cell) | 0.76 ± 0.21 | 0.84 ± 0.20 | 0.86 ± 0.25 | 0.09 | 0.02 |
| 142 | 36 | 6 | 0.006 | 0.002 | |
P values are given for both additive and recessive models (CC vs. CA + AA) due to the small number of AA (n = 6) with measures of fat cell size. All P values were calculated after adjusting for age, sex, and birth year. P values for fat cell size were additionally adjusted for percent body fat. SNP rs8050136 is in linkage disequilibrium with rs9939609 and rs7193144 (not shown).