TABLE 2.

Genotypic association with diabetic nephropathy and type 2 diabetes

	Hardy-Weinberg equilibrium		Genotypic association
			2 d.f.	Dominant			Additive			Recessive
	Case subjects	Control subjects	P	P	OR	CI	P	OR	CI	P	OR	CI
Diabetic nephropathy vs. nondiabetic
Admixture	0.024	0.060	0.0019	0.0015	1.37	1.13–1.67	0.0393	1.16	1.01–1.34	0.6442	0.94	0.71–1.24
Age			0.0032	0.0009	1.49	1.18–1.89	0.0081	1.26	1.06–1.49	0.6225	1.09	0.78–1.53
BMI			0.0008	0.0004	1.46	1.19–1.80	0.0110	1.22	1.05–1.42	0.9334	0.99	0.73–1.34
Sex			0.0017	0.0013	1.38	1.13–1.67	0.0378	1.16	1.01–1.34	0.6330	0.93	0.70–1.24
Combined				0.0019	1.46	1.15–1.86	0.0114	1.25	1.05–1.49	0.5593	1.11	0.79–1.56
Type 2 diabetes + diabetic nephropathy vs. nondiabetic
Admixture	0.003	0.061	0.0003	0.0003	1.40	1.17–1.67	0.0196	1.17	1.03–1.33	0.5549	0.92	0.71–1.20
Age			0.0006	0.0002	1.50	1.21–1.86	0.0058	1.25	1.07–1.46	0.8796	1.02	0.75–1.40
BMI			0.0001	0.0001	1.47	1.21–1.79	0.0075	1.22	1.05–1.41	0.7473	0.95	0.72–1.27
Sex			0.0002	0.0002	1.41	1.17–1.69	0.0187	1.17	1.03–1.34	0.5110	0.92	0.70–1.19
Combined				0.0005	1.48	1.19–1.84	0.0088	1.24	1.06–1.45	0.8408	1.03	0.75–1.42

Genotypic association for rs182052 after individual adjustment for admixture, age, BMI, and sex in 851 type 2 diabetes + diabetic nephropathy case subjects versus 871 nondiabetic control subjects and type 2 diabetes + diabetic nephropathy case subjects plus an additional 317 type 2 diabetic (no nephropathy) subjects (total cases = 1,168) versus the same 871 nondiabetic control subjects. Genotypic association is also shown for all four covariates simultaneously (combined).