TABLE 3.
Survival analysis to estimate risk of early age at onset of type 2 diabetes and ESRD
| Dominant
|
Recessive
|
Additive
|
||||
|---|---|---|---|---|---|---|
| P | RR | P | RR | P | RR | |
| Age at onset of type 2 diabetes | ||||||
| Diabetic nephropathy | 0.0003 | 1.29 | 1.0000 | 1.00 | 0.0102 | 1.14 |
| Type 2 diabetes | 0.0031 | 1.41 | 0.9714 | 0.99 | 0.0338 | 1.19 |
| Diabetic nephropathy + type 2 diabetes | 0.0002 | 1.26 | 0.9217 | 1.01 | 0.0063 | 1.13 |
| After adjustment | ||||||
| Diabetic nephropathy | 0.0011 | 1.27 | 0.9391 | 0.99 | 0.0192 | 1.13 |
| Type 2 diabetes | 0.0034 | 1.42 | 0.7143 | 0.94 | 0.0507 | 1.17 |
| Diabetic nephropathy + type 2 diabetes | 0.0004 | 1.25 | 0.9878 | 1.00 | 0.0091 | 1.12 |
| Age at onset of ESRD | ||||||
| Diabetic nephropathy | 0.0113 | 1.20 | 0.1443 | 1.17 | 0.0098 | 1.14 |
| After adjustment for sex, BMI, and admixture | ||||||
| Diabetic nephropathy | 0.0084 | 1.21 | 0.1148 | 1.18 | 0.0063 | 1.16 |
| After adjustment for age at onset of type 2 diabetes | ||||||
| Diabetic nephropathy | 0.86 | 0.99 | 0.34 | 1.11 | 0.73 | 1.03 |
P values and RRs are reported for the dominant, additive, and recessive models both before and after adjustment for sex, BMI, and admixture proportions. Analysis of age at onset of ESRD is also adjusted for age at onset of type 2 diabetes.