TABLE 2.
BMI-stratified analyses for FTO and TCF7L2 loci in replication samples
| Obese type 2 diabetes vs. control subjects
|
Nonobese type 2 diabetes vs. control subjects
|
Pdiff | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| RSA (n = 1,718/3,596) | RSB (n = 362 /1,750) | RSA + RSB | WTCCC + RS | Passoc | RSA (n = 1,407/3,596) | RSB (n = 270 /1,750) | RSA + RSB | WTCCC + RS | Passoc | ||
| FTO (rs8050136) | 1.20 (1.10–1.30) | 1.29 (1.09–1.53) | 1.22 (1.13–1.32) | 1.30 (1.23–1.39) | 1.7 × 10−17 | 1.06 (1.96–1.16) | 1.07 (0.88–1.29) | 1.05 (0.97–1.15) | 1.06 (1.00–1.14) | 0.06 | 1.4 × 10−7 |
| TCF7L2 (WTCCC imputed) | 1.24 (1.13–1.36) | 1.44 (1.20–1.72) | 1.28 (1.18–1.39) | 1.31 (1.23–1.40) | 6.1 × 10−16 | 1.50 (1.36–1.65) | 1.45 (1.19–1.77) | 1.48 (1.36–1.62) | 1.49 (1.39–1.59) | 9.1 × 10−30 | 0.002 |
| TCF7L2 (WTCCC naive) | 1.24 (1.13–1.36) | 1.44 (1.20–1.72) | 1.28 (1.18–1.39) | 1.25 (1.17–1.34) | 1.3 × 10−11 | 1.50 (1.36–1.65) | 1.45 (1.19–1.77) | 1.48 (1.36–1.62) | 1.51 (1.41–1.61) | 2.9 × 10−32 | 4.0 × 10−6 |
Stratification in the RS samples is based on the case median BMI from the WTCCC (30.2 kg/m2). Numbers in column headers refer to number of case and control subjects. RR estimates by strata are generated from multinomial logistic regression. For meanings of “imputed” and “naive” analyses, see the supplementary information. Passoc represents the P value for type 2 diabetes association derived from meta-analysis including WTCCC data; PDIFF represents a test for between-strata heterogeneity.