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. 2009 Jan 7;9:1. doi: 10.1186/1472-6769-9-1

Figure 2.

Figure 2

Cell-free topoisomerase II alpha and beta interaction studies with substituted purine analogues. (A) Chemical structures of biotinylated purine analogue 2 (compound (cpd) 2), purine analogues 3 (cpd 3) and 4 (cpd 4), respectively. (B) Binding of both topoisomerase II alpha and beta to 1 μM biotinylated purine analogue 1 and disruption of binding by parent compound 3 but not ATPase inactive compound 4 (both at 10 μM). (C) Binding of topoisomerase II alpha and beta to 1 μM biotinylated compound 1 is abolished by 10 fold molar excess and equimolar concentrations of QAP 1.