Table 3.
RR estimates for developing type 2 diabetes by circulating levels of resistin in men and women, separately
| Variable | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Ptrend | Continuous (per 1 SD increase)* |
|---|---|---|---|---|---|---|
| Women (case patients/control subjects) | 56/90 | 87/88 | 88/91 | 127/89 | ||
| Basic model† | 1.00 | 1.63 (1.03–2.58) | 1.60 (1.01–2.52) | 2.35 (1.50–3.69) | <0.001 | 1.37 (1.17–1.59) |
| Full model‡ | 1.00 | 1.38 (0.84–2.27) | 1.40 (0.84–2.35) | 2.22 (1.32–3.73) | 0.002 | 1.36 (1.14–1.61) |
| Full model + BMI | 1.00 | 1.43 (0.85–2.40) | 1.36 (0.81–2.30) | 1.51 (0.86–2.65) | 0.20 | 1.17 (0.98–1.39) |
| Full model + CRP§ | 1.00 | 1.12 (0.64–1.95) | 1.03 (0.60–1.76) | 1.18 (0.68–2.07) | 0.60 | 1.10 (0.92–1.32) |
| Full model + BMI + CRP§ | 1.00 | 1.24 (0.72–2.16) | 1.13 (0.66–1.95) | 1.13 (0.63–2.01) | 0.85 | 1.07 (0.89–1.28) |
| Men (case patients/control subjects) | 54/59 | 26/45 | 38/28 | 52/38 | ||
| Basic model† | 1.00 | 0.76 (0.39–1.51) | 1.01 (0.54–1.87) | 1.53 (0.82–2.85) | 0.09 | 1.21 (0.98–1.48) |
| Full model‡ | 1.00 | 0.73 (0.34–1.53) | 1.10 (0.57–2.12) | 1.51 (0.75–3.02) | 0.13 | 1.23 (0.99–1.53) |
| Full model + BMI | 1.00 | 0.53 (0.23–1.22) | 0.80 (0.35–1.86) | 1.19 (0.54–2.62) | 0.38 | 1.19 (0.91–1.56) |
| Full model + TNF-RII§ | 1.00 | 0.71 (0.33–1.51) | 1.06 (0.54–2.06) | 1.42 (0.68–2.98) | 0.18 | 1.22 (0.97–1.53) |
| Full model + BMI + TNF-RII§ | 1.00 | 0.56 (0.24–1.32) | 0.93 (0.38–2.28) | 1.39 (0.56–3.46) | 0.26 | 1.26 (0.94–1.71) |
Data are RR (95% CI).
*
RR per 1 SD increase in log-transformed values of resistin.
†
Basic model adjusted for matching factors (i.e., age, ethnicity, and fasting status at time of blood draw).
‡
Full model adjusted for matching factors and diabetes risk factors (i.e., alcohol intake, exercise, cigarette smoking status, and family history of diabetes).
§
As an inflammatory marker, TNF-RII was adjusted in the PHS II because the CRP measure was not available.