Table 1.
Treatment targets for variables and percent decrease in incidence of MIs as a result of normalizing variable values to reach treatment targets
| Target for normalization | Decrease in incidence of MIs (fatal and nonfatal) | |
|---|---|---|
| Insulin resistance | Average value at ages 20–30 years | 42 |
| SBP (mmHg) | 114 | 36 |
| HDL cholesterol (mg/dl) | 46 (men), 54 (women) | 31 |
| BMI (kg/m2) | 22.5 | 21 |
| LDL cholesterol (mg/dl) | 108 | 16 |
| Triglycerides (mg/dl) | 108 | 10 |
| FPG (mg/dl) | 86 | 9 |
| Smoking | Never smoke | 9 |
| Family history | No family history | 4 |
| Causality not established | ||
| FFA (mg/dl) | 20 | 18 |
| C-reactive protein (mg/dl) | 0.32 | 10 |
| ApoB (mg/dl) | 85 | 9 |
| Lipoprotein(a) (mg/dl) | 57 (blacks), 21.5 (nonblacks) | 9 |
| Homocysteine (μmol/l) | 7.0 | 5 |
| All variables | NA | 94 |
Data for decrease in myocardial infarction are percent. Treatment targets represent the average values for people aged 20–30 years in the U.S. population. NA, not applicable.