Table 2.

Dose-Dependent Tyramine Response: Prediction by SNPs in Presynaptic Pathway

			Repeated-Measures ANOVA
Gene Function/Locus Name	Domain	Position*	F Statistic	P
Catecholamine biosynthesis
TH	Promoter	C-824T	0.59	0.88
DBH	Promoter	C-1021T	0.31	0.99
CYB561	Intron 1	C719G	2.80	<0.001
Catecholamine storage
CHGA	3′-UTR	C11825T	1.62	0.06
CHGA	Exon 6	Glu246Asp	0.88	0.60
CHGA	Promoter	G-462A	1.28	0.21
CHGB	3′-UTR	C13612A	1.45	0.12
CHGB	Exon 4	Glu348Glu	2.44	0.002
Catecholamine transport
VMAT1=SLC18A1	3′-UTR	T38292C	1.30	0.20
VMAT2=SLC18A2	Intron 12	C25851T	1.32	0.23
NET1=SLC6A2	Exon 9	Thr429Thr	1.25	0.23
Storage vesicle acidification
ATP6V1A	Intron 1	A31599G	1.00	0.46
ATP6V1B1	Exon 1	Ile30thr	1.74	0.038
Catecholamine metabolism  and degradation
MAOA	Exon 8	Arg297Arg	3.32† (1.26‡)	<0.001 (0.27)
MAOB	Intron 13	A113683G	0.75† (0.81‡)	0.73 (0.60)
FMO3	Exon 4	Glu158Lys	1.33	0.18
COMT	Exon 4	Met158Val	0.56	0.91

All analyses performed with ethnicity as a covariate. Sexes were evaluated separately for SNPs on the X chromosome (MAOA, MAOB).

^*For position notations, see legend for Table 1.

^†From female subjects only

^‡from male subjects only.

Data in parentheses are for male subjects only. Degrees of freedom for repeated-measures ANOVA: df=8 within subjects, df=2 between subjects, and df=16 for genotype-by-dose interaction.