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. 2009 Feb 6;5(2):e1000361. doi: 10.1371/journal.pgen.1000361

Figure 1. Deletion of Individual sod Genes Does Not Decrease Lifespan Despite Increasing Sensitivity to Oxidative Stress.

Figure 1

A–E) sod-1(A), sod-3(C), sod-4(D) and sod-5(E) mutant worms live as long as wild-type N2 worms while sod-2 mutant worms (B) live significantly longer than wild-type worms. F–J) sod-1 (F), sod-2 (G) and sod-3 (H) mutant worms showed decreased survival on 4 mM paraquat plates compared to N2 worms, while sod-4 (I) and sod-5 (J) mutant worms survived as long as N2 worms. K–O) Similarly, sod-1 (K) and sod-2 (L) mutant worms showed decreased survival on 240 µM juglone plates compared to N2 worms, while the survival of sod-3 (M), sod-4 (N) and sod-5 (O) mutant worms was not significantly different than N2 worms. Overall, sod deletion increases sensitivity to oxidative stress but does not decrease lifespan. * p<0.05, ** p<0.01, ***p<0.001.