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. 2009 Feb 6;5(2):e1000361. doi: 10.1371/journal.pgen.1000361

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Van Raamsdonk, Hekimi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) None of the sod-1 double deletion mutants showed a decreased lifespan compared to wild-type or sod-1 mutant worms. sod-1;sod-2 mutant worms show extended longevity. B) All of the sod-2 double deletion mutants exhibited extended lifespan compared to wild-type worms. C) Despite exhibiting a normal or extended lifespan, all of the sod-1 double deletion mutants as well as sod-2;sod-3 mutant worms were very sensitive to paraquat-induced oxidative stress. D) As with the paraquat assay, sod-1 double deletion mutants and sod-2;sod-3 mutant worms showed the greatest sensitivity to juglone-induced oxidative stress. Overall, sod-sod double deletion mutants show increased sensitivity to oxidative stress but exhibit a normal or extended lifespan.