Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Feb 6;5(2):e1000361. doi: 10.1371/journal.pgen.1000361

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Van Raamsdonk, Hekimi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

To model sod-1 and sod-2 knockouts in species which have only three sod genes, sod-1;sod-3;sod-5 (A) and sod-2;sod-3;sod-5 (B) mutant worms were generated respectively. sod-1;sod-2;sod-4 (C) mutant worms which lack the primary cytoplasmic, mitochondrial and extracellular sod genes were also generated. Surprisingly, none of the sod triple deletion mutants showed decreased lifespan compared to wild-type worms and the two triple mutants bearing the sod-2 allele lived significantly longer than wild-type. Thus, C. elegans is able to compensate for the loss of multiple sod genes to achieve a normal or extended lifespan.