Figure 6. sod-2 Mutant Worms Exhibit the Hallmark Features of Extended Longevity Mitochondrial Mutants in C. elegans.

Similar to extended longevity mitochondrial mutants such as clk-1 and isp-1, sod-2 mutant worms show slow post-embryonic development (A), slow defecation rate (B), decreased self-brood size (C) and long life (D). In clk-1 worms, the deletion of sod-2 slows development, slows defecation rate, decreases brood size and increases lifespan. In isp-1 worms, sod-2 deletion slows development, increases defecation rate, decreases brood size and decreases lifespan. *p<0.05, **p<0.01, ***p<0.001.