Figure 1. Thioglycollate peritonitis in three generations of PECAM-deficient mice.

Thioglycollate peritonitis (TGP) was performed as described in Materials and Methods. All bars show mice that received 1 mL of 4% thioglycollate broth intraperitoneally. The mean inflammatory score and standard error of that mean is shown for each generation of knockout mice generated during the crossing of FVB and B6 PECAM-deficient mice. Data include 14 FVB mice, 14 B6 mice, 6 F₁ BxF mice, 7 F₁ FxB mice, and 110 F₂ mice. *: groups vary from each other significantly; **: group varies from several other groups significantly; ***: group varies from all other groups significantly; detailed statistical comparisons are reported in Supplemental Table S1.