Figure 4. Medium-density QTL mapping results.

Using a proprietary allele-specific primer extension based assay, the Illumina GoldenGate technology, the QTL peak was narrowed to a point at 35.8 Mb (panel A). Near this well-defined peak are four genes of particular interest (panel B, colored circles at top of graph, from left to right): Ptges, coding for mPGES-1 (prostaglandin E₂ synthase 1, green); Ptges2, coding for PGES-2 (prostaglandin E₂ synthase 2, blue); Hc, coding for hemolytic complement component C5 (black); and Ptgs1, coding for the protein commonly known as COX-1 (red); these four genes are also indicated in the lower row of genes identified in Figure 3B. The LOD score = 3.0 threshhold for significance is inidcated by a horizontal grey line in both panels.