Table 2.
Summary of pharmacokinetic parameters of healthy subjects given a single intravenous infusion of CDA1 by dose level
| Dose, mg/kg | Tmax, h | Cmax μg/ml | AUC, h*μg/ml | Vd, L/kg | MRT, h | T1/2, h | CL, ml/min/kg |
|---|---|---|---|---|---|---|---|
| 0.3 | 5.0 (2.4, 25.9) | 7.0 (5.9, 7.4) | 3042 (2516, 4022) | 0.070 (0.064, 0.081) | 926 (843, 1873) | 684 (628, 1350) | 0.0012 (0.0006, 0.0015) |
| 1.0 | 2.6 (2.3, 3.0) | 24.7 (18.8, 35.4) | 8902 (6457, 10804) | 0.081 (0.062, 0.097) | 917 (724, 1258) | 684 (548, 953) | 0.0014 (0.0010, 0.0019) |
| 5.0 | 3.0 (2.5, 4.7) | 112.7 (77.9, 134.4) | 47530 (41162, 52660) | 0.071 (0.067, 0.093) | 981 (812, 1155) | 728 (537, 824) | 0.0013 (0.011, 0.0015) |
| 10.0 | 2.6 (2.5, 10.0) | 227.7 (194.5, 245.0) | 84357 (72193, 86444) | 0.079 (0.076, 0.097) | 913 (663, 1365) | 660 (481, 1015) | 0.0014 (0.0012, 0.0019) |
| 20.0 | 3.9 (3.0, 5.0) | 479.1 (430.1, 638.0) | 174632 (144521, 242411) | 0.076 (0.048, 0.085) | 704 (615, 1136) | 550 (472, 846) | 0.0014 (0.0011, 0.0020) |
NOTE. Data are median (range). Tmax, time to maximum serum drug concentration after start of infusion; Cmax, maximum serum concentration; AUC, area under the serum concentration time curve to the last collection time; Vd, volume of distribution; MRT, mean residence time; T1/2, terminal elimination phase half-life; CL, drug clearance.