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Expression of Myc-repressed miRNAs disadvantages lymphoma cell growth in vivo. (a) Myc3 or 38B9 lymphoma cells were infected with a retrovirus expressing a miRNA and GFP. The percentage of GFP-positive cells was measured before and after tumor formation. (b) Cells expressing select miRNAs are eliminated from tumors. Data are mean ± s.d. from three independent trials. At least 30% of cells were positive for GFP before injection into recipient mice.
